AZD 5582 dihydrochloride
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产品名称:
AZD 5582 dihydrochloride
产品型号:
GOY-Y1922
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-25
简单介绍
AZD 5582 dihydrochlorideSoluble in DMSO
AZD 5582 dihydrochloride
的详细介绍
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性能参数
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产品名称
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AZD 5582 dihydrochloride
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规格
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10 mg
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货号
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GOY-Y1922
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含量
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>97.00%
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CAS
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1883545-51-4
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别名
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N/A
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化学名
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N/A
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分子式
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C58H78N8O8.2HCl
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分子量
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分子 1088.21
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溶解度
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Soluble in DMSO
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.
Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J.Med.Chem. 56 9897 PMID:24320998
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