性能参数

产品名称

ASK1-IN-2

规格

10mM*1 mL in DMSO 5 mg 10 mg 25 mg 50 mg 100 mg

货号

GOY-Y1916

 含量

>98.00%

CAS

2541792-70-3

别名

N/A

化学名

N/A

分子式

C19H17FN6O

分子量

分子 364.38

溶解度

DMSO : 250 mg/mL (686.10 mM; Need ultrasonic)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

ASK1-IN-2 (compound 19) (10 mM; 1 h) inhibits the luciferase reporter activity in AP1-HEK293 cells, with inhibition rate of 95.59%[1].

ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) improves dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice[1].ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) blocks ASK1-p38/JNK signaling pathways and reduces inflammatory cytokine levels in DSS-induced mouse colon tissues[1].ASK1-IN-2 (1 mg/kg; i.v.) shows low clearance (CL=1.38 L/h/kg) and moderate half-life (T1/2=1.45 h) in rats[1].ASK1-IN-2 (10 mg/kg; p.o.) shows high oral exposure (AUClast=4517 h?ng/mL), 62.2% oral bioavailability and acceptable terminal half-life (T1/2=2.31 h) in rats[1].

[1]. Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114.

溴代异丁烷 98%  甲烷磺酰氯 99.5%（剧毒品）

溴代环戊烷 99%  邻苯二甲酰氯 90%

2,4-二氯苯酚   CP,98%  均苯四甲酸酐 96%

2,6-二氯苯酚 AR,99.0%  琥珀酰亚胺 98%

2,4,6-三溴苯酚 98%  2,3-二甲基-1-丁烯 98%

2,4,6-三氯苯酚 98%  2,3-二甲基-2-丁烯 98%

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PF-0381473510mM * 1 mL in DMSO 5mg 10mg 50mg>99.00%Cas No. 942487-16-3C23H25F3N6O2

BETd-260 (ZBC 260)10mM*1mLinDMSO5mg 10mg 25mg 50mg>99.00%Cas No. 2093388-62-4C43H46N10O6

BMS-9862025 mg 10 mg 25 mg 50 mg 100 mg>99.00%Cas No. 1771691-34-9C22H18D3FN6O3

CC-9001010mM*1 mL in DMSO5 mg 10 mg 50 mg 100 mg>99.00%Cas No. 1706738-98-8C21H21NO4S

AZD53055 mg 10 mg 25 mg 50 mg 100 mg>99.00%Cas No. 2589531-76-8C22H26N6O2

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