性能参数

产品名称

Apremilast 

规格

10mM (in 1mL DMSO) 5mg 10mg 25mg 50mg

货号

GOY-Y1907

 含量

>98.00%

CAS

608141-41-9

别名

N/A

化学名

N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide

分子式

C22H24N2O7S

分子量

分子 460.5

溶解度

≥ 23.05 mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Apremilast, also known as CC-10004, is a novel and potent small-molecule inhibitor of phosphodiesterase 4 (PDE4), a key enzyme involved in cyclic adenosine monophosphate (cAMP) degradation and cytokine production of inflammatory cells. Apremilast binds to the catalytic site of PDE4, with values of inhibition constant IC50 and affinity constant Kiof 0.074 μM and 68 nM respectively, consequently leading to the degradation of cAMP. Apremilast exhibits anti-inflammatory activities against inflammatory disease in animal models as well as human chronic inflammatory diseases (such as psoriasis and psoriatic arthritis) by blocking the synthesis of a range of pro-flammatory cytokines and chemokines, including tumor necrosis factor alpha, interleukin 23, CXCL9 and CXCL10.

Reference

[1].Georg Schett, Victor S. Sloan, Randall M. Stevens and Peter Schafer. Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory disease. Ther Adv Musculoskelet Dis. 2010; 2(5): 271-278

2,5-二羰基吡咯烷-1-基2-(苄氧基羰基氨基)乙酸酯  98.5%  2-甲基琥珀酸  99%

Cbz-L-组氨酸  99%  N-苄基甘氨酸乙酯 97%

Z-L-酪氨酸甲酯  98.5%  苯基丁二酸 98%

N-CBZ-L-丝氨酸 98%  DL-α-氨基 98%

Z-Ser(Tos)-OMe 98.5%  对甲 99%

Z-O-叔丁基-D-丝氨酸  98.5%  硫代水杨酸 99%

PX 1210mM (in 1mL DMSO) 10mg 50mg>98.00%Cas No. 141400-58-0C7H12N2S2

RVX-20810mM (in 1mL DMSO) 5mg 20mg>98.00%Cas No. 1044870-39-4C20H22N2O5

Santacruzamate A (CAY10683)10mM (in 1mL DMSO) 10mg 50mg>98.00%Cas No. 1477949-42-0C15H22N2O3

2',3',5'-triacetyl-5-Azacytidine5mg  10mg 50mg 100mg>98.00%Cas No. 10302-78-0C14H18N4O8

A-9664925mg  10mg 50mg 200mg>98.00%Cas No. 934162-61-5C18H17FN4O

AZD24615mg  10mg 50mg 100mg>98.00%Cas No. 1174043-16-3C22H22FN3O3