性能参数

产品名称

ASK1-IN-1

规格

1mg 5mg 10mg 50mg 100mg

货号

GOY-Y1902

 含量

>98.00%

CAS

1262041-49-5

别名

N/A

化学名

N/A

分子式

C23H21N7O

分子量

分子 411.46

溶解度

DMSO : 15.5 mg/mL (37.67 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4.

ASK1-IN-1 dose-dependently decreases pulmonary arterial pressure and right ventricular (RV) hypertrophy in an in vivo model of pulmonary hypertension (PH). ASKl inhibition reduces hallmarks of pulmonary vascular disease including and not limited to reduce pulmonary vascular resistance (PVR), improve pulmonary pressure, decreased pulmonary vascular remodeling, improved vascular function, decrease maladaptive RV hypertrophy, and improve RV function. Inhibition of ASKl signaling may slow, prevent, and/or reverse pathological changes associated with PH. Plasma levels of B-type natriuretic peptide (BNP) are reduced by both doses of ASK1-IN-1: 0.1+0.05 for 0.1% and 0.1±0.1 ng/mL for 0.2%. Su/Hx rats treated with 0.1 % or 0.2% ASK1-IN-1 has a decreased number of completely muscularized arterioles (35.6% and 32.6%, respectively)[1].

References:

[1]. Grant Raymond BUDAS, et al. Methods of treating pulmonary hypertension. WO2016025474A1.

N-苄氧羰基-L-脯氨酸 98%  糠醛 standard for GC, ≥99.5% (GC)

CBZ-L-赖氨酸 98%  糠醛 ≥98%, FCC

Cbz-L-脯氨酸酰胺 98%  氨基甲酸铵 97%

Z-D-Asp(OtBu)-OH·H2O 98%  氨基甲酸铵 GR

N-苄氧羰基-L-丙氨酸 98%  L-羟基脯氨酸 99%

N-苄氧羰基-L-色氨酸 98%  L-赖氨酸二盐酸盐 98%

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BI-95645mg  25mg 100mg>98.00%Cas No. 1883429-22-8C20H23N3O3

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