性能参数

产品名称

(R)-CR8 trihydrochloride

规格

10mM*1mL in DMSO 5mg 10mg 50mg 100mg

货号

GOY-Y1886

 含量

>98.00%

CAS

1786438-30-9

别名

N/A

化学名

N/A

分子式

C24H32Cl3N7O

分子量

分子 540.92

溶解度

DMSO: 62.5 mg/mL (115.54 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

(R)-CR8 trihydrochloride (CR8 trihydrochloride), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2].

[1]. Bettayeb K, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. [2]. Kabadi SV, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13.

Pam Resin 0.5~1.5mmol/g, 100~200 mesh, 1% DVB  多**素 分析标准品，90%

Polystyrene Resin 100-200 mesh, 1% DVB  敌百虫 分析标准品，99%

人体胰脏多肽 ≥95% (HPLC)  敌百虫标准溶液 100μg/ml,u=4%

Prolactin-releasing Peptide human ≥97% (HPLC)  敌百虫标准溶液 10μg/ml,u=7%

Phe-Met-Arg-Phe amide ≥95% (H?

dTRIM2410mM*1mL in DMSO5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 2170695-14-2C55H68N8O13S2

EPZ56762mg 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 1380288-87-8C30H42N8O3

FNDR-2012310mM*1 mL in DMSO5 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. N/AC21H24ClN5O2

FL-411 (BRD4-IN-1)10mM*1mLinDMSO5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 2118944-88-8C18H19N3O2S

FG-4592 (ASP1517)10mM (in 1mL DMSO)10mg 50mg 100mg 200mg 500mg>98.00%Cas No. 808118-40-3C19H16N2O5