性能参数
产品名称
(5Z,2E)-CU-3
规格
5mg 10mg 25mg 50mg 100mg
货号
GOY-Y1884
含量
>98.00%
CAS
1815598-71-0
别名
N/A
化学名
分子式
C16H12N2O4S3
分子量
分子 392.47
溶解度
DMSO: 20 mg/mL (50.96 mM; ultrasonic and warming and heat to 60°C); H2O: < 0.1 mg/mL (insoluble)
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.
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产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!