性能参数

产品名称

ATB-346

规格

10mM (in 1mL DMSO) 10mg 50mg 100mg

货号

GOY-Y1874

 含量

>98.00%

CAS

1226895-20-0

别名

N/A

化学名

4-carbamothioylphenyl 2-(6-methoxynaphthalen-2-yl)propanoate

分子式

C21H19NO3S

分子量

分子 365.45

溶解度

≥ 18.27mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

ATB-346 is a hydrogen sulphide-releasing anti-inflammatory drug [1].

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) and shows a markedly reduced toxicity than its parent compound naproxen. In the airpouch model, ATB-346 significantly inhibited the PGE2 level and completely suppressed the whole blood TXB2 synthesis without causing gastric damage. In rats with adjuvant-Induced arthritis, administration of ATB-346 reduced the paw volume on days 14 and 21 notably. ATB-346 did not exert any damage or bleeding in the stomach or small intestine while naproxen caused bleeding in the small intestine. Besides that, administration of naproxen twice daily for 5 days in rats resulted in extensive damage in the small intestine. In contrast, same dose of ATB-346 caused quite little damage over the treatment of the 5 days [1].

References:

[1] Wallace J L, Caliendo G, Santagada V, et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). British journal of pharmacology, 2010, 159(6): 1236-1246.

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3-硝基-L-酪氨酸 98%  吡嘧磺隆 分析标准品，99%

神经降压素  ≥95% (HPLC)  丙草胺 分析标准品，97.5%

Boc-D-精氨酸盐酸盐 BR  丙草胺标准溶液100μg/ml,u=2%,溶剂:甲醇

Fmoc-1-Nal-Wang resin 100-200mesh,Substitution 0.3-0.8mmol/g  丙草胺标准溶液10μg/ml,u=2%,溶剂:甲醇

Fmoc-2-Nal-Wang resin 100-20?

DDP-38003 dihydrochloride1mg 5mg 10mg 50mg 100mg>98.00%Cas No. 1831167-98-6C21H28Cl2N4O

DC_51710mM*1mLinDMSO2mg 5mg 10mg 50mg>98.00%Cas No. 500017-70-9C33H35N3O2

DC-0510mM*1mLinDMSO2mg 5mg 10mg 50mg>98.00%Cas No. 890643-16-0C25H25N3O

EDO-S1011mg 5mg 10mg 25mg 50mg>98.00%Cas No. 1236199-60-2C19H28Cl2N4O2

EBI-25115mg 10mg 25mg 50mg 100mg>98.00%Cas No. 2098546-05-3C34H48N4O4