性能参数

产品名称

Apcin

规格

1mg 5mg 10mg 25mg

货号

GOY-Y1873

 含量

>98.00%

CAS

300815-04-7

别名

N/A

化学名

[2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester

分子式

C13H14Cl3N7O4

分子量

分子 438.7

溶解度

DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C). Apcin competitively binds to Cdc20 and prevents substrate interaction and ubiquitylation required for continuation of mitosis. Apcin enhances the effect of the APC/C inhibitor N-4-tosyl-L-arginine methyl ester and its prodrug, proTAME, leading to an increase in the number of cells in mitosis, a longer mitotic duration, and greater stabilization of cyclin B1, cycB1-NT, securin, and cyclin A2. Apcin, in combination with proTAME, synergistically increases apoptosis in multiple myeloma cells.

References:

[1]. Sackton, K.L., Dimova, N., Zeng, X., et al. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C Nature 514(7524), 646-649 (2014).

[2]. Lub, S., Maes, A., De Veirman, K., et al. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells Oncotarget 7(4), 4062-4076 (2016).

Mastoparan-7 ≥97% (HPLC)  扑草净标准溶液 100μg/ml,u=4%

Mastoparan 17 ≥96.5%  抗蚜威 分析标准品，99%

DL-正亮氨酸 98%  抗蚜威标准溶液 100μg/ml,u=2%

L-正缬氨酸 99%  抗蚜威标准溶液 10μg/ml,u=4%

N'-硝基-L-精氨酸 98%  甲基对硫磷标准溶液 100μg/ml,u=2%;基体 丙酮

N-硝基-L-精氨酸甲酯 98%  甲基对硫磷标准溶液 10μg/ml,u=4%;基体 丙酮

CEP-3377910mM (in 1mL DMSO)5mg 10mg 50mg 100mg>98.00%Cas No. 1257704-57-6C24H26N6O2S

CeMMEC15mg 10mg 25mg 50mg 100mg>98.00%Cas No. 440662-09-9C19H16N2O4

CCT12920210mM (in 1mL DMSO)5mg 10mg 50mg 200mg>98.00%Cas No. 942947-93-5C23H25ClN8OS

CG347B5mg 10mg 50mg 100mg 250mg>98.00%Cas No. 1598426-03-9C16H17N3O2

CPI-16125 mg 10 mg 25 mg 50 mg 100 mg>98.00%Cas No. 2374971-81-8C27H26N6O

dBET12mg 5mg 10mg 25mg 50mg>98.00%Cas No. 1799711-21-9C38H37ClN8O7S

CX-6258 hydrochloride hydrate5mg 10mg 50mg 100mg 200mg>98.00%Cas No. 1353858-99-7C26H27Cl2N3O4