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Amarogentin

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产品名称: Amarogentin
产品型号: GOY-Y1872
产品展商: 谷研
产品文档: 无相关文档
发布时间:2023-04-25

简单介绍

AmarogentinDMF: 1 mg/ml,DMSO: 2 mg/ml,PBS (pH 7.2): 0.1 mg/ml


Amarogentin  的详细介绍

性能参数

产品名称

Amarogentin

规格

1mg 5mg 10mg 25mg

货号

GOY-Y1872

 含量

>98.00%

CAS

21018-84-8

别名

N/A

 

 

化学名

N/A

分子式

C29H30O13

分子量

分子 586.5

溶解度

DMF: 1 mg/ml,DMSO: 2 mg/ml,PBS (pH 7.2): 0.1 mg/ml

储存条件

Store at -20°C

General tips

 

用途

仅供科研

价格

电询

详细内容

Amarogentin is a secoiridoid glycoside that has been found in Swertia and has diverse biological activities, including anticancer, antidiabetic, and anti-leishmanial properties. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 μM after 48 hours) and increases apoptosis when used at a concentration of 50 μM. Amarogentin (10-50 mg/kg, s.c.) dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. It reduces plasma glucose levels in a rat model of diabetes induced by streptozotocin in a dose-dependent manner and reverses the STZ-induced increase in soleus muscle levels of glucose transporter 4 (Glut4) when administered at a dose of 0.5 mg/kg. Amarogentin reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner.

 

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