2,3-Dimethoxy-5-methyl-p-benzoquinone
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产品名称:
2,3-Dimethoxy-5-methyl-p-benzoquinone
产品型号:
GOY-Y1861
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-25
简单介绍
2,3-Dimethoxy-5-methyl-p-benzoquinoneDMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 0.2 mg/ml
2,3-Dimethoxy-5-methyl-p-benzoquinone
的详细介绍
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性能参数
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产品名称
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2,3-Dimethoxy-5-methyl-p-benzoquinone
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规格
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1g 5g 10g 25g
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货号
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GOY-Y1861
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含量
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>98.00%
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CAS
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605-94-7
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别名
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N/A
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化学名
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N/A
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分子式
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C9H10O4
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分子量
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分子 182.2
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溶解度
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DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 0.2 mg/ml
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E. It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 μM, respectively) with a cytotoxic concentration of greater than 40 μM for non-cancerous ovarian surface epithelial cells. It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.
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