性能参数

产品名称

3,5-dimethyl PIT-1

规格

1mg 5mg 10mg 25mg

货号

GOY-Y1863

 含量

>98.00%

CAS

701947-53-7

别名

N/A

化学名

N/A

分子式

C16H15N3O4S

分子量

分子 345.4

溶解度

DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 0.2 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM). 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.

0.3~0.8mmol/g, 100~200 mesh, 1% DVB  异稻瘟净标准溶液 10μg/ml,u=6%

肯普肽 ≥95% (HPLC)  抑霉唑标准溶液100μg/ml,u=2%,溶剂:甲醇

Kinetensin ≥97% (HPLC)  抑霉唑标准溶液10μg/ml,u=2%,溶剂:甲醇

L-赖氨酸乙酯二盐酸盐 98%  异恶唑草酮 分析标准品，99%

L-赖氨酸甲酯盐酸盐 98%  苯氧菌酯 分析标准品，97%

N-碳苄氧基赖氨酸 98%  春雷霉素 分析标准品，72.5%

ENMD-119 (ENMD 1198)1mg  5mg 10mg 20mg>98.00%Cas No. 864668-87-1C20H25NO2

Fisetin10mM (in 1mL DMSO) 100mg 500mg 1g>98.00%Cas No. 528-48-3C15H10O6

GDC-03392mg  5mg 10mg 50mg>98.00%Cas No. 1428569-85-0C20H22F3N7OS

G007-LK10mM (in 1mL DMSO) 5mg 25mg 100mg>98.00%Cas No. 1380672-07-0C25H16ClN7O3S

GSK31173915mg  10mg 25mg 50mg>98.00%Cas No. 1018673-42-1C22H33N3O4

GSK199 (hydrochloride)500μg  1mg 5mg 10mg>98.00%Cas No. 1549811-53-1C24H28N6O2?HCl