(S)-Gossypol acetic acid
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产品名称:
(S)-Gossypol acetic acid
产品型号:
GOY-Y1859
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-25
简单介绍
(S)-Gossypol acetic acidDMSO: 50 mg/mL (86.41 mM); H2O: < 0.1 mg/mL (insoluble)
(S)-Gossypol acetic acid
的详细介绍
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性能参数
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产品名称
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(S)-Gossypol acetic acid
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规格
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10mg 50mg 100mg 200mg
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货号
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GOY-Y1859
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含量
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>98.00%
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CAS
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1189561-66-7
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别名
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N/A
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化学名
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N/A
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分子式
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C32H34O10
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分子量
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分子 578.61
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溶解度
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DMSO: 50 mg/mL (86.41 mM); H2O: < 0.1 mg/mL (insoluble)
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储存条件
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Store at -20°C, protect from light, stored under nitrogen
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity. Bcl-2 Bcl-xL
The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (S)-Gossypol ((+)-Gossypol) enantiomers. (+)-Gossypol and (-)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities. (-)-Gossypol is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001)[1].
[1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.
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