性能参数

产品名称

(-)-(α)-Kainic Acid (hydrate)

规格

1mg 10mg 25mg 50mg

货号

GOY-Y1856

 含量

>98.00%

CAS

58002-62-3

别名

N/A

化学名

2S-carboxy-4S-(1-methylethenyl)-3S-pyrrolidineacetic acid, monohydrate

分子式

C10H15NO4 ? H2O

分子量

分子 231.2

溶解度

50mg/ml in PBS

储存条件

Store at RT

General tips

用途

仅供科研

价格

电询

详细内容

Kainic acid is a natural marine product originally isolated from the red marine alga D. Simplex. It is a potent central nervous system stimulant, and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice.[1] Kainic acid is neuroexcitotoxic and epileptogenic, acting through specific kainate receptors.[2]

Reference:

[1]. Marsicano, G., Goodenough, S., Monory, K., et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302(5642), 84-88 (2003).

[2]. Ferkany, J.W., Zaczek, R., and Coyle, J.T. Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature 298(19), 757-759 (1982).

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