性能参数 |
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产品名称 |
Antagonist G (trifluoroacetate salt) |
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规格 |
1 mg 5 mg 10 mg |
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货号 |
GOY-Y1847 |
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含量 |
>98.00% |
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CAS |
N/A |
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别名 |
N/A |
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化学名 |
N/A |
分子式 |
C49H66N12O6S·XCF3COOH |
分子量 |
分子 951.2 |
溶解度 |
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 20 mg/ml |
储存条件 |
-20°C |
General tips |
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用途 |
仅供科研 |
价格 |
电询 |
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详细内容 |
Antagonist G is a neuropeptide antagonist.1,2,3 It inhibits the binding of vasopressin to rat liver or Swiss 3T3 membranes (IC50s = 3.5 and 2.2 μM, respectively) and vasopressin-induced production of inositol phosphate in Swiss 3T3 fibroblasts (IC50 = 1 μM).1 Antagonist G (50 μM) induces apoptosis and the production of reactive oxygen species (ROS) in NCI H69 small cell lung cancer (SCLC) cells.2 It reduces tumor growth in an NCI H69 mouse xenograft model when administered at a dose of 45 μg/g.3 1.Seckl, M.J., Newman, R.H., Freemont, P.S., et al.Substance P-related antagonists inhibit vasopressin and bombesin but not 5’-3-O-(thio)triphosphate-stimulated inositol phosphate production in swiss 3T3 cellsJ. Cell Physiol.163(1)87-95(1995) 2.MacKinnon, A.C., Waters, C., Rahman, I., et al.[Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapyBr. J. Cancer.83(7)941-948(2000) 3.Langdon, S., Sethi, T., Ritchie, A., et al.Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivoCancer Res.52(16)4554-4557(1992) . |
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