性能参数

产品名称

Amifostine (hydrate)

规格

50mg 100mg 500mg

货号

GOY-Y1845

 含量

>98.00%

CAS

112901-68-5

别名

N/A

化学名

N/A

分子式

C5H15N2O3PS?3H2O

分子量

分子 268.3

溶解度

PBS (pH 7.2): 5 mg/ml

储存条件

Store at 2-8°C

General tips

用途

仅供科研

价格

电询

详细内容

Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities. Because of the differential expression of alkaline phosphatase in normal versus neoplastic tissues, the cytoprotection conferred by amifostine is selective, enabling as much as 100-fold greater accumulation of WR 1065 in normal tissues than in tumor cells. Amifostine has been used to reduce toxicity in normal tissues exposed to radiation or chemotherapeutic agents. In mouse fibroblasts and various cancer cells, amifostine (IC50 = 4 mM) has been shown to activate p53 protein, to induce the expression of the cyclin-dependent kinase inhibitor p21, and to arrest cells at the G1/S transition through a p53-dependent mechanism.

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N-Fmoc-N-甲基-O-叔丁基-L-丝氨酸 98%  异菌脲标准溶液 10μg/ml,u=6%

N-Fmoc-N-甲基-O-叔丁基-L-苏氨酸 98%  p, p’-DDE标准溶液100μg/ml,u=3%,溶剂:石油醚

Fmoc-N-甲基-L-缬氨酸 98%  p, p’-DDE标准溶液10μg/ml,u=3%,溶剂:石油醚

Fmoc-N-甲基-D-缬氨酸 98%  p, p’-DDT标准溶液100μg/ml,u?

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