性能参数

产品名称

AEM1

规格

500μg 1mg 5mg

货号

GOY-Y1844

 含量

>98.00%

CAS

1030123-90-0

别名

N/A

化学名

N/A

分子式

C20H14FN3O2S

分子量

分子 379.4

溶解度

DMF: 30 mg/mL,DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL,DMSO: 20 mg/mL,Ethanol: 0.25 mg/mL

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation. AEM1 is an inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 μM. It sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the growth of A549 cells in vitro and in vivo in animals. The effectiveness of AEM1 against cancer cells is restricted to those harboring mutations that render Nrf2 constitutively active.

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