性能参数

产品名称

ACBI1

规格

100mg 250mg 500mg

货号

GOY-Y1836

 含量

>98.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C49H58FN9O7S

分子量

分子 936.1

溶解度

DMSO: ≥ 100 mg/mL (106.83 mM)

储存条件

Store at -20°C, protect from light, stored under nitrogen

General tips

用途

仅供科研

价格

电询

详细内容

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis[1]. DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)[1]

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.

FMOC-L-蛋氨酸五氟苯基酯  96%  丁硫克百威溶液10μg/ml,溶剂:丙酮

Fmoc-D-蛋氨酸 98%  环庚草醚 分析标准品，92%

Fmoc-L-脯氨酸五氟苯酯   96%  甲基毒死蜱标准溶液 10μg/ml,u=6～4%，丙酮

Fmoc-丝氨酸磷酸苄酯 98%  甲基毒死蜱标准溶液 100μg/ml,u=6～4%，丙酮

Fmoc-Ser(tBu)-OPfp 98%  克菌丹标准溶液 100μg/ml,u=3%

芴甲氧羰基-O-苄基-L-苏氨酸 98%  克菌丹标准溶液 10μg/ml?

JAK1-IN-4250mg 500mg>98.00%Cas No. 2091134-35-7C26H32FN9O2

JAK1-IN-3250mg 500mg>98.00%Cas No. 2091134-68-6C25H31N9O2

JAK-IN-1250mg 500mg>98.00%Cas No. 1334673-53-8C20H24N6O2

L Moses dihydrochloridemg 50 mg>98.00%Cas No. N/AC21H24N6.2HCl

LLY-283250mg 500mg>98.00%Cas No. 2040291-27-6C17H18N4O4

Lin28-let-7a antagonist 1250mg 500mg>98.00%Cas No. 2024548-03-4C31H29N5O7

L-45 dihydrochloride (L-Moses dihydrochloride)5mg 10mg>98.00%Cas No. N/AC21H26Cl2N6