性能参数
产品名称
A23187 (calcium magnesium salt)
规格
1mg 5mg 10mg
货号
GOY-Y1831
含量
>98.00%
CAS
N/A
别名
Calcimycin
化学名
5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid, calcium salt (2:1) 5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(
分子式
[C29H36N3O6]2 Ca ?[C29H36N3O6]2 Mg
分子量
分子 523.6
溶解度
3mg/mL in ethanol or DMF
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways.[1] A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.[2],[3]
Reference:
[1]. Sullivan, T.J., and Parker, C.W. Pharmacologic modulation of inflammatory mediator release by rat mast cells. Am. J. Pathol. 85(2), 437-464 (1976).
[2]. Maecker, H.T., Hedjbeli, S., Alzona, M., et al. Comparison of apoptosis signaling through T cell receptor, Fas, and calcium ionophore. Exp. Cell Res. 222(1), 95-102 (1996).
[3]. Cho, S.Y., Lee, J.H., Bae, H.D., et al. Transglutaminase 2 inhibits apoptosis induced by calcium-overload through down-regulation of Bax. Exp. Mol. Med. 42(9), 639-650 (2010).
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