性能参数

产品名称

7,8-Dihydroxyflavone

规格

10mM (in 1mL DMSO) 10mg 50mg

货号

GOY-Y1827

 含量

>98.00%

CAS

38183-03-8

别名

化学名

7,8-dihydroxy-2-phenyl-4H-chromen-4-one

分子式

C15H10O4

分子量

分子 254.24

溶解度

≥ 12.75mg/mL in DMSO

储存条件

Store at 4°C, stored under nitrogen

General tips

用途

仅供科研

价格

电询

详细内容

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].

7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1].

7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2].

References:

[1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50.

公司正在销售的产品：

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!