性能参数

产品名称

9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester

规格

1mg 5mg 10mg

货号

GOY-Y1824

 含量

>98.00%

CAS

42021-86-3

别名

N/A

化学名

N/A

分子式

C20H34O2

分子量

分子 306.5

溶解度

DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 100 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

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