性能参数

产品名称

4-oxo Withaferin A

规格

1mg 10mg 5mg

货号

GOY-Y1822

 含量

>98.00%

CAS

6850-30-2

别名

N/A

化学名

N/A

分子式

C28H36O6

分子量

分子 468.6

溶解度

DMF: 5mg/mL,DMSO: 5mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.

References

1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).

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