4-oxo-27-TBDMS Withaferin A
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产品名称:
4-oxo-27-TBDMS Withaferin A
产品型号:
GOY-Y1821
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-25
简单介绍
4-oxo-27-TBDMS Withaferin ADMF: 5mg/mL,DMSO: 5mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
4-oxo-27-TBDMS Withaferin A
的详细介绍
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性能参数
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产品名称
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4-oxo-27-TBDMS Withaferin A
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规格
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1mg 5mg 10mg
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货号
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GOY-Y1821
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含量
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>98.00%
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CAS
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1214886-31-3
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别名
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N/A
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化学名
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N/A
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分子式
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C34H50O6Si
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分子量
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分子 582.9
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溶解度
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DMF: 5mg/mL,DMSO: 5mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.
References
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).
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